Newborn and Infant Nursing Reviews
Volume 8, Issue 1 , Pages 18-29, March 2008

Disorders of Fatty Acid Oxidation in the Era of Tandem Mass Spectrometry in Newborn Screening☆

  • Sandra A. Banta-Wright, RNC, MN, NNP

      Affiliations

    • Child Development and Rehabilitation Center, Oregon Health and Science University, Portland, OR
    • Oregon Institute on Disability and Development, Child Development and Rehabilitation Center, Oregon Health and Science University, Portland, OR
    • Corresponding Author InformationAddress correspondences to Sandra A. Banta-Wright, RNC, MN, NNP, LEND Training Program, Child Development and Rehabilitation Center, Oregon Health and Science University, 707 SW Gaines Road, Portland, OR 97239. Tel.: +1 503 703 1895.
    • ,
  • Kathleen C. Shelton, PhD, PNP

      Affiliations

    • Child Development and Rehabilitation Center, Oregon Health and Science University, Portland, OR
    • ,
  • Michael J. Bennett, PhD, FRCPath, FACB

      Affiliations

    • University of Pennsylvania, Evelyn Willing Bromley Endowed Chair in Clinical Laboratory Medicine and Pathology
    • Metabolic Disease Laboratory, The Children's Hospital of Philadelphia, Philadelphia, PA

With recent advances in laboratory technology with tandem mass spectrometry (MS/MS), the number of infants identified with a fatty acid oxidation disorder has increased dramatically. Disorders of fatty acid oxidation comprise one of the most rapidly growing groups within the field of errors of metabolism. This review will explore the recent developments in newborn screening related to the use of tandem mass spectrometry and disorders of fatty acid oxidation.

Keywords: Fatty acid oxidation, Tandem mass spectrometry

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☆ This work was supported by T-73 MC000034, a training grant from the Maternal-Child Health Bureau for Leadership, Education in Neurodevelopmental and Related Disabilities (LEND) Program.

PII: S1527-3369(07)00194-8

doi:10.1053/j.nainr.2007.12.014

Newborn and Infant Nursing Reviews
Volume 8, Issue 1 , Pages 18-29, March 2008

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